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Studies also examine synaptic-plasticity mechanisms and angiotensin-derived peptide signaling across in-vitro and ex-vivo research systems
Elevated MOTS-c levels in senescent cells, which are exposed to these peptides, increased mitochondrial respiration and some senescence-associated secretory phenotypes (SASP) in the former, suggesting that mitochondria-secreted peptides exert a therapeutic effect by targeting mitochondrial energy and SASP production in senescent cells 50
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